In an ovenproof skillet over medium-high heat, cook ground beef, stirring and breaking apart until no longer pink. Drain grease and return beef to skillet.
Add garlic powder, onion powder, Italian seasoning, salt, and pepper to the beef and stir well to combine.
Add cream cheese and pasta sauce to the skillet. Heat over medium-low, stirring frequently, until cream cheese is completely melted and sauce is smooth.
Stir in cooked rotini and mix until fully coated in sauce.
Top evenly with shredded mozzarella cheese.
Broil for 2 to 5 minutes, watching closely, until cheese is bubbly and melted.
Top with chopped fresh parsley if desired and serve immediately.